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List of Contributors ix Preface xv 1 Introduction: Two Centuries of Progress in Transfusion Medicine 1 Walter H. (Sunny) Dzik and Michael F. Murphy Part I Basic Principles of Immunohaematology 11 2 Essential Immunology for Transfusion Medicine 11 Jaap Jan Zwaginga and S. Marieke van Ham 3 Human Blood Group Systems 20 Geoff Daniels 4 Human Leucocyte Antigens 29 Cristina V. Navarrete and Colin J. Brown 5 Platelet and Neutrophil Antigens 43 Brian R. Curtis 6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58 Mark H. Yazer and Meghan Delaney Part II Complications of Transfusions 69 7 Investigation of Acute Transfusion Reactions 69 Kathryn E. Webert and Nancy M. Heddle 8 Haemolytic Transfusion Reactions 81 Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman 9 Febrile and Allergic Transfusion Reactions 97 Mark K. Fung and Nancy M. Heddle 10 Lung Injury and Pulmonary Oedema After Transfusion 108 Steven H. Kleinman and Daryl J. Kor 11 Purported Adverse Effects of Old Blood 118 Lirong Qu and Darrell J. Triulzi 12 Transfusion ]Induced Immunomodulation 125 Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg 13 Transfusion ]Associated Graft ]Versus ]Host Disease and Microchimerism 136 Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer 14 Posttransfusion Purpura 147 Michael F. Murphy 15 Transfusion ]Transmitted Infections 153 Roger Y. Dodd and Susan L. Stramer 16 Bacterial Contamination 168 Sandra Ramirez ]Arcos and Mindy Goldman 17 Emerging Infections and Transfusion Safety 176 Roger Y. Dodd Part III Practice in Blood Centres and Hospitals 184 18 Regulatory Aspects of Blood Transfusion 184 William G. Murphy, Louis M. Katz and Peter Flanagan 19 The Role of Haemovigilance in Transfusion Safety 193 Katharine A. Downes and Barbee I. Whitaker 20 Donors and Blood Collection 203 Marc Germain, Ellen McSweeney and William G. Murphy 21 Blood Donation Testing and the Safety of the Blood Supply 215 Mindy Goldman 22 Production and Storage of Blood Components 222 Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo 23 Blood Transfusion in Hospitals 233 Erica M. Wood, Mark H. Yazer and Michael F. Murphy 24 Blood Transfusion in a Global Context 254 David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney Part IV Clinical Transfusion Practice 264 25 Inherited and Acquired Coagulation Disorders 264 Irina Chibisov and Franklin Bontempo 26 Massive Blood Loss 279 John R. Hess 27 Blood Management in Acute Haemorrhage and Critical Care 287 Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh 28 Point ]of ]Care Testing in Transfusion Medicine 302 Matthew D. Neal and Louis H. Alarcon 29 Haematological Disease 312 Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy 30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330 Enrico M. Novelli 31 Heparin ]Induced Thrombocytopenia 341 Andreas Greinacher and Theodore E. Warkentin 32 Immunodeficiency and Immunoglobulin Therapy 357 Siraj A. Misbah 33 Transfusing Neonates and Infants 371 Ronald G. Strauss Part V Patient Blood Management 383 34 Development of a Patient Blood Management Programme 383 Jonathan H. Waters 35 Perioperative Patient Blood Management 393 Martin Rooms, Ravishankar Rao Baikady and Toby Richards 36 Restrictive Transfusion Practice and How to Implement It 405 Lawrence Tim Goodnough and Neil Shah 37 Using Data to Support Patient Blood Management 416 Steven M. Frank and Jack O. Wasey Part VI Cellular and Tissue Therapy and Organ Transplantation 429 38 Regulation and Accreditation in Cellular Therapy 429 Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman 39 Stem Cell Collection and Therapeutic Apheresis 442 Khaled El ]Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski 40 Haemopoietic Stem Cell Processing and Storage 455 Hira Mian, Ronan Foley and Pamela O Hoski 41 Haematopoietic Stem Cell Transplantation 466 Robert D. Danby, Rachel Protheroe and David J. Roberts 42 Cord Blood Transplantation 477 Rachael Hough and Robert D. Danby 43 Recent Advances in Clinical Cellular Immunotherapy 490 Mark W. Lowdell and Emma Morris 44 Tissue Banking 500 Akila Chandrasekar, Paul Rooney and John N. Kearney Part VII Development of the Evidence Base for Transfusion 508 45 Observational and Interventional Trials in Transfusion Medicine 508 Alan T. Tinmouth, Dean Fergusson and Paul C. Hebert 46 Getting the Most Out of the Evidence for Transfusion Medicine 520 Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree and Sally Hopewell 47 A Primer on Biostatistics 533 Andrew W. Shih and Nancy M. Heddle 48 A Primer on Health Economics 549 Seema Kacker and Aaron A. R. Tobian 49 Scanning the Future of Transfusion Medicine 560 Jay E. Menitove, Paul M. Ness and Edward L. Snyder Index 572

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